A Pilot Study of Value of Information Analysis to Support Research Recommendations for NICE

Background CHE Discussion Papers (DPs) began publication in 1983 as a means of making current research material more widely available to health economists and other potential users. So as to speed up the dissemination process, papers were originally published by CHE and distributed by post to a worldwide readership. The new CHE Research Paper series takes over that function and provides access to current research output via web-based publication, although hard copy will continue to be available (but subject to charge). Disclaimer Papers published in the CHE Research Paper (RP) series are intended as a contribution to current research. Work and ideas reported in RPs may not always represent the final position and as such may sometimes need to be treated as work in progress. The material and views expressed in RPs are solely those of the authors and should not be interpreted as representing the collective views of CHE research staff or their research funders. Access to downloaded material is provided on the understanding that it is intended for personal use. Copies of downloaded papers may be distributed to third-parties subject to the proviso that the CHE publication source is properly acknowledged and that such distribution is not subject to any payment. Printed copies are available on request at a charge of £5.00 per copy. Please contact the CHE Publications Office, email [email protected], telephone 01904 321458 for further details. Contents Page Executive summary iii Chapter 1: Introduction and overview of methods 1 Chapter 2: The cost-effectiveness and value of information associated with repeat screening for age related macular degeneration 12 Chapter 3: Glycoprotein IIb/IIIa antagonists for the treatment of acute coronary syndromes 26 Chapter 4: Clopidogrel and modified-release dipyridamole in the secondary prevention of occlusive vascular events 41 Chapter 5: The cost-effectiveness and value of information associated with treatment for influenza in otherwise healthy adults 58 Chapter 6: Liquid-based cytology for cervical screening 74 Chapter 7: Disease-modifying therapies for the management of multiple Sclerosis 87 Chapter 8: Implications, methodological issues and challenges 100 Chapter 9: Implementing value of information analysis in the NICE research and development process 107 Chapter 10: Conclusions 113 ii A pilot study of value of information analysis in the methods and application of decision analysis and value of information analysis as a means of informing the research recommendations made by NICE, as part of its Guidance to the NHS in England and Wales, and informing …